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Buy LONG STACK 300 mg Injectable Steroids $92.00 Cut Mix, cheap price order steroids online gain muscle. FARMACOCINETICA Y FARMACODINAMIA: Inhibidor esteroideo de la aromatasa, agente antineoplasico: El exemestano es un inactivador esteroideo de la aromatasa, irreversible, relacionado estructuralmente con el sustrato natural androstenediona. En mujeres posmenopausicas, los estrogenos se producen principalmente de la conversion de androgenos a estrogenos a traves de la enzima aromatasa en los tejidos perifericos. La privacion de estrogeno a traves de la inactivacion de la aromatasa es un tratamiento efectivo y selectivo para el cancer de mama dependiente de hormonas en mujeres posmenopausicas. En mujeres posmenopausicas, el exemestano redujo significativamente las concentraciones de estrogeno serico con una dosis inicial de 5 mg, y alcanzando la supresion maxima (> 90%) con dosis de 10-25 mg. 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Se ha observado un ligero incremento en los niveles sericos de LH y FSH que no es dependiente de la dosis, aun con dosis bajas; este efecto es, sin embargo, el esperado para la clase farmacologica, y es probablemente el resultado de la retroalimentacion a nivel de la pituitaria, debido a la reduccion en los niveles de estrogeno que estimulan la secrecion de gonadotropinas en la pituitaria en mujeres posmenopausicas. Tratamiento coadyuvante del cancer de mama en estadios iniciales: En un estudio multicentrico, aleatorizado, doble ciego, realizado en 4,724 pacientes posmenopausicas con cancer de mama y receptor estrogenico positivo o desconocido, que habian permanecido sin la enfermedad, despues de recibir tratamiento coadyuvante con tamoxifeno durante 2 o 3 anos, fueron aleatorizadas para recibir exemestano (25 mg/dia) o tamoxifeno (20 o 30 mg/dia) durante 2 a 3 anos, hasta completar un total de 5 anos de terapia hormonal. 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Resultados de un subestudio endometrial indicaron que despues de 2 anos de tratamiento hubo una mediana de reduccion en el grosor endometrial de 33% en los pacientes tratados con exemestano en comparacion con una no notable variacion en los pacientes tratados con tamoxifeno. El engrosamiento endometrial, reportado al inicio del tratamiento de estudio, revirtio a la normalidad en 54% de los pacientes tratados con exemestano. Tratamiento del cancer de mama avanzado: En un estudio clinico, fase 3 realizado por la EORTC (Organizacion Europea para la Investigacion y Tratamiento del Cancer), el exemestano se comparo con el tamoxifeno como tratamiento de primera linea del cancer de mama avanzado. Los resultados indicaron que los pacientes en el grupo de tratamiento del exemestano presentaron una media mayor del tiempo de Supervivencia Sin Progresion (PFS), en comparacion con el tamoxifeno (9. Asimismo, los pacientes tratados con exemestano presentaron un mayor indice de respuesta al tumor objetivo, en comparacion con el tamoxifeno (44 vs. En un estudio clinico, controlado, aleatorizado y revisado por expertos, se demostro que la dosis diaria de 25 mg de exemestano produce un aumento estadisticamente significativo en la supervivencia, del Tiempo hasta la Progresion (TTP) y del Tiempo hasta el Fracaso del Tratamiento (TFT), en comparacion con el tratamiento hormonal estandar con acetato de megestrol en pacientes posmenopausicas con cancer de mama avanzado, que ha progresado despues o durante el tratamiento con tamoxifeno, ya sea como terapia coadyuvante o como tratamiento de primera linea para la enfermedad avanzada.

 

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