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Measurements: Incidence rates of severe adverse events in steroid burst users and non-steroid users, as well as incidence rate ratios (IRRs) for severe adverse events within 5 to 30 and 31 to 90 days after initiation of steroid therapy, anabolic steroid control act of 1990. Results: Of 15 859 129 adult participants, 2 623 327 who received a single steroid burst were included. The most common indications were skin disorders and respiratory tract infections. The incidence rates per 1000 person-years in steroid bursts were 27. Rates of GI bleeding (IRR, 1. Limitation: Persons younger than 20 years or older than 64 years were not included. Conclusion: Oral corticosteroid bursts are frequently prescribed in the general adult population in Taiwan. The highest rates of GI bleeding, sepsis, and heart failure occurred within the first month after initiation of steroid therapy. Primary funding source: National Health Research Institutes, Ministry of Science and Technology of Taiwan, Chang Gung Medical Foundation, and Eunice Kennedy Shriver National Institute of Child Health and Human Development. Medically reviewed by Drugs. Last updated on April 9, 2021. Applies to the following strengths: 10 mg; 2. Usual Adult Dose for: Allergic Reaction Ankylosing Spondylitis Aspiration Pneumonia Bursitis Dermatitis Herpetiformis Hypercalcemia of Malignancy Idiopathic (Immune) Thrombocytopenic Purpura Loeffler’s Syndrome Osteoarthritis Polymyositis/Dermatomyositis Psoriasis Rheumatoid Arthritis Sarcoidosis Seborrheic Dermatitis Systemic Lupus Erythematosus Ulcerative Colitis – Active Uveitis Iritis Optic Neuritis Gouty Arthritis Hemolytic Anemia Anti-inflammatory Immunosuppression Neoplastic Diseases Rheumatic Heart Disease Adrenocortical Insufficiency Corneal Ulcers Keratitis Pemphigus Mycosis Fungoides Psoriatic Arthritis Epicondylitis Iridocyclitis Choroiditis Synovitis Thrombocythemia Stevens-Johnson Syndrome Serum Sickness Multiple Sclerosis Asthma – Acute Nephrotic Syndrome Asthma – Maintenance. Usual Pediatric Dose for: Allergic Reaction Ankylosing Spondylitis Aspiration Pneumonia Bursitis Dermatitis Herpetiformis Hypercalcemia of Malignancy Loeffler’s Syndrome Osteoarthritis Polymyositis/Dermatomyositis Psoriasis Sarcoidosis Seborrheic Dermatitis Systemic Lupus Erythematosus Ulcerative Colitis – Active Uveitis Iritis Optic Neuritis Gouty Arthritis Hemolytic Anemia Anti-inflammatory Immunosuppression Neoplastic Diseases Rheumatic Heart Disease Adrenocortical Insufficiency Corneal Ulcers Keratitis Pemphigus Mycosis Fungoides Juvenile Rheumatoid Arthritis Psoriatic Arthritis Epicondylitis Iridocyclitis Chorioretinitis Choroiditis Berylliosis Synovitis Thrombocythemia Stevens-Johnson Syndrome Serum Sickness Erythema Multiforme Nephrotic Syndrome Asthma – Acute Asthma – Maintenance. Additional dosage information: Renal Dose Adjustments Liver Dose Adjustments Dose Adjustments Precautions Dialysis Other Comments. Usual Adult Dose for Allergic Reaction. Dosing should be individualized based on disease and patient response : Initial dose: 5 to 60 mg orally per day Maintenance dose: Adjust or maintain initial dose until a satisfactory response is obtained; then, gradually in small decrements at appropriate intervals decrease to the lowest dose that maintains an adequate clinical response. Comments : -Exogenous corticosteroids suppress adrenocorticoid activity the least when given at the time of maximal activity; consider time of maximal adrenal cortex activity (2 to 8 AM) when dosing. Uses: As an anti-inflammatory or immunosuppressive agent when corticosteroid therapy as appropriate, such as for the treatment of certain allergic states; nervous system, neoplastic, or renal conditions; endocrine, rheumatologic, or hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, or gastrointestinal diseases; specific infectious diseases or conditions related to organ transplantation. Usual Adult Dose for Ankylosing Spondylitis. Dosing should be individualized based on disease and patient response : Initial dose: 5 to 60 mg orally per day Maintenance dose: Adjust or maintain initial dose until a satisfactory response is obtained; then, gradually in small decrements at appropriate intervals decrease to the lowest dose that maintains an adequate clinical response. Comments : -Exogenous corticosteroids suppress adrenocorticoid activity the least when given at the time of maximal activity; consider time of maximal adrenal cortex activity (2 to 8 AM) when dosing. Uses: As an anti-inflammatory or immunosuppressive agent when corticosteroid therapy as appropriate, such as for the treatment of certain allergic states; nervous system, neoplastic, or renal conditions; endocrine, rheumatologic, or hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, or gastrointestinal diseases; specific infectious diseases or conditions related to organ transplantation. Usual Adult Dose for Aspiration Pneumonia. 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