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A potent alternative to Pred Forte is Durezol (difluprednate ophthalmic emulsion 0. This ‘designer’ steroid adds two fluorine atoms to the prednisone molecule to increase its strength. Because Durezol is an emulsion, it does not require shaking to deliver an equal amount of active ingredient with each drop. This may be an advantage when treating patients with anterior uveitis who may require dosing every hour with prednisone. Research shows that Durezol four times a day is as good as prednisolone acetate eight times a day; however, it is worth noting that Durezol is more likely to increase IOP than prednisone. Topical dexamethasone and fluorometholone , like prednisolone, are corticosteroid suspension eye drops that have been available for years. Both medications are less potent than prednisolone and are considered viable alternatives when clinicians need to mitigate the risks of a stronger steroid. This patient presented with a corneal abrasion and hypopyon. He was treated successfully with a bandage contact lens, a topical steroid and a topical antibiotic. Click image to enlarge. To further decrease the risk of increased IOP or other events, many optometrists will look to ‘soft steroids. Two of the oldest and most well-known are Alrex (loteprednol etabonate ophthalmic suspension 0. The weaker of the two, Alrex, is approved for temporary relief of the signs and symptoms of seasonal allergic conjunctivitis. Lotemax, with more than twice the potency of Alrex, is approved for pain and inflammation after cataract surgery along with other inflammatory conditions such as iritis and allergic conjunctivitis. The ointment is approved for use after multiple ocular surgeries, including LASIK, cataract, minimally invasive glaucoma surgeries and Descemet’s stripping endothelial keratoplasty. Two gel formulations exist, Lotemax gel (loteprednol etabonate 0. Both have similar indications as the suspension and ointment. One major benefit of the gel formulation is that it ensures a consistent amount of active drug in each drop without the need for shaking. The newest member of the family is Lotemax SM, which uses what the manufacturer calls ‘submicron technology’ to help the medication adhere to the ocular surface. This is designed to improve penetration to the targeted tissues, including presence within the aqueous humor. With four different Lotemax products to choose from, clinicians have to consider several factors when deciding what to prescribe, including efficacy, availability and affordability. Ointments are great because they don’t require shaking, stay on the eye and can provide some lubrication. However, they can blur vision, and some patients may struggle to instill the proper one-half inch ribbon dose, norditropin simplexx 15iu human growth hormone $150.00 norditropin. Lotemax gel and Lotemax SM do not need shaking and may require less dosing, but new products may be more expensive and not as widely available. In August 2018, Inveltys (loteprednol etabonate ophthalmic suspension 1%, Kala Pharmaceuticals) was approved for postoperative pain and inflammation after ocular surgery.
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